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Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

Abstract:

Objective: There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach. Methods: A two-stage study design was utilised. 123 knee osteoarthritis cases and 299 controls were selected from the TwinsUK cohort as a discovery sample. 76 knee osteoarthritic cases and 100 controls from the Chingford Study were used as replication. Knee osteoarthritis was defined as eit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/ard.2009.120857

Authors


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Institution:
King's College London
Department:
Department of Twin Research and Genetic Epidemiology
Role:
Author
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Institution:
Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany
Department:
Institute of Epidemiology
Role:
Author
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Institution:
King's College London
Department:
Department of Twin Research and Genetic Epidemiology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Research group:
NIHR Oxford Biomedical Research Unit
Role:
Author
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Institution:
Whipps Cross Hospital, London, UK
Department:
Department of Rheumatology
Role:
Author
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Wellcome Trust More from this funder
Arthritis Research Campaign More from this funder
European Community More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
69
Issue:
6
Pages:
1227-1231
Publication date:
2010-01-01
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Language:
English
Keywords:
Subjects:
UUID:
uuid:ffd6f7cf-3652-4656-940e-f932fced6133
Local pid:
ora:4896
Deposit date:
2011-02-04

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