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Thesis

The roles of BRCA2 in chromosome integrity

Abstract:

High frequency of fork stalling and fork degradation are associated with DNA damage accumulation and represent key replication pathologies in cells lacking BRCA2. As a consequence, these cells enter mitosis with under-replicated DNA, which leads to interlinks between sister chromatids in anaphase. Failure to resolve these interlinks causes chromosome mis-segregation, aneuploidy and micronuclei. Here we show that BRCA2 loss leads to micronuclei formation, which triggers an innate immune respon...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
St Cross College
Role:
Author
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Programme:
Marie Sklodowska-Curie / European Union’s Horizon 2020 Research and Innovation programme
Grant:
722729
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-05-02

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