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Defining childhood severe falciparum malaria for intervention studies

Abstract:

Background: Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although there is no ‘‘gold standard’’ individual test for severe malaria, malaria-attributable fractions (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.0040251

Authors


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Institution:
"Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
4
Issue:
8
Article number:
e251
Publication date:
2007-08-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Language:
English
Subjects:
UUID:
uuid:faf352fe-bef7-443a-90af-a84f0bb83cec
Local pid:
ora:3075
Deposit date:
2009-11-25

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