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Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations

Abstract:

More than 90% of children in Africa are infected with cytomegalovirus (CMV) by the age of 12 months. However, the high-frequency, immunodominant CD8+ T-cell responses that control CMV infection have not been well studied in African populations. We therefore sought to define the immunodominant CMV-specific CD8+ T-cell responses within sub-Saharan African study subjects. Among 257 subjects, we determined the CD8+ T-cell responses to overlapping peptides spanning three of the most immunogenic CM...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0189612

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-5325-3453
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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More from this funder
Grant:
WT104748MA to PJRG
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
12
Article number:
e0189612
Publication date:
2017-12-12
Acceptance date:
2017-11-29
DOI:
ISSN:
1932-6203
Pmid:
29232408
Source identifiers:
812206
Language:
English
Pubs id:
pubs:812206
UUID:
uuid:fa75e883-2bf8-457a-8336-faef5323d612
Local pid:
pubs:812206
Deposit date:
2018-01-27

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