Journal article
Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells
- Abstract:
-
Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors but the downstream mechanisms have only been partially elucidated. Here we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca2+ and PKA activity and hormone release measurements. We found that stimulation of glucagon secretion correlated with a PKA- and EPAC2-dependent (inhibited by PKI and ESI-05, respectively) elevation...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Oxford Biomedical Research Council
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Diabetes UK
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Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 67
- Issue:
- 6
- Pages:
- 1128-1139
- Publication date:
- 2018-03-21
- Acceptance date:
- 2018-03-13
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Pmid:
-
29563152
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:831029
- UUID:
-
uuid:fa63526b-c205-4ea7-a098-5ee61b5181b5
- Local pid:
- pubs:831029
- Source identifiers:
-
831029
- Deposit date:
- 2018-04-04
Terms of use
- Copyright holder:
- *Copyright holder name ("et al" as required)*
- Copyright date:
- 2018
- Notes:
- © 2018 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license. This is the accepted manuscript version of the article. The final version is available online from the American Diabetes Association at: http://dx.doi.org/10.2337/db17-1102
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