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Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells

Abstract:

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors but the downstream mechanisms have only been partially elucidated. Here we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca2+ and PKA activity and hormone release measurements. We found that stimulation of glucagon secretion correlated with a PKA- and EPAC2-dependent (inhibited by PKI and ESI-05, respectively) elevation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db17-1102

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
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Diabetes UK More from this funder
Oxford Biomedical Research Council More from this funder
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
67
Issue:
6
Pages:
1128-1139
Publication date:
2018-03-21
Acceptance date:
2018-03-13
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pmid:
29563152
Source identifiers:
831029
Language:
English
Keywords:
Pubs id:
pubs:831029
UUID:
uuid:fa63526b-c205-4ea7-a098-5ee61b5181b5
Local pid:
pubs:831029
Deposit date:
2018-04-04

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