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Heterozygosity increases microsatellite mutation rate, linking it to demographic history

Abstract:

Background: Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely that mutation rate and population size are indpendent, because population expansion would increase heterozygosity that in turn would increase mutation rate. Here we test this hypothes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2156-9-72

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, WTC Human Genetics
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC Genetics Journal website
Volume:
9
Article number:
72
Publication date:
2008-11-14
Acceptance date:
2008-11-14
DOI:
EISSN:
1471-2156
Source identifiers:
41067
Language:
English
Keywords:
Pubs id:
pubs:41067
UUID:
uuid:f9eb4436-f85b-4b74-9852-84f8ff51e060
Local pid:
pubs:41067
Deposit date:
2012-12-19

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