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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Abstract:

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biologic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41588-018-0321-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
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Kadoorie Charitable Foundation More from this funder
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Grant:
202922/Z/16/Z
088158/Z/09/Z
104085/Z/14/Z
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
51
Pages:
481–493
Publication date:
2019-02-25
Acceptance date:
2018-10-17
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:930485
URN:
uri:f827f6be-cdee-454c-95be-b048ab05ce15
UUID:
uuid:f827f6be-cdee-454c-95be-b048ab05ce15
Local pid:
pubs:930485

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