The role of p53 in hypoxia-induced apoptosis
Tumour hypoxia is associated with resistance to therapy, increased aggressiveness and a poor patient prognosis. The tumour suppressor p53 causes apoptosis in response to hypoxia and therefore hypoxic tumours select for the loss of p53.
In this work was we have investigated the post-translational modifications and binding partners of p53 in hypoxia. Furthermore, we investigated the p53-dependent gene expression changes in hypoxia.
We have shown that p53 is stabilised and phosp...Expand abstract
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- University of Oxford
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- Poole, R
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