Thesis
The role of p53 in hypoxia-induced apoptosis
- Abstract:
-
Tumour hypoxia is associated with resistance to therapy, increased aggressiveness and a poor patient prognosis. The tumour suppressor p53 causes apoptosis in response to hypoxia and therefore hypoxic tumours select for the loss of p53.
In this work was we have investigated the post-translational modifications and binding partners of p53 in hypoxia. Furthermore, we investigated the p53-dependent gene expression changes in hypoxia.
We have shown that p53 is stabilised and phosp...
Expand abstract
Actions
Access Document
- Files:
-
-
(pdf, 1.0MB)
-
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Contributors
+ Hammond, E
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2010
- Type of award:
- MSc
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:f64d1a96-9657-4426-b94f-b3f94fe25823
- Local pid:
- ora:6349
- Deposit date:
- 2012-07-10
Terms of use
- Copyright holder:
- Poole, R
- Copyright date:
- 2012
If you are the owner of this record, you can report an update to it here: Report update to this record