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Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Abstract:
Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c6ob02616h

Authors


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Institution:
University of Oxford
Oxford college:
St Edmund Hall
Role:
Author
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Funding agency for:
Hopkinson, R
Grant:
William R. Miller Junior Research Fellowship
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Funding agency for:
Kawamura, A
Grant:
Dorothy Hodgkin Research Fellowship
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic and Biomolecular Chemistry Journal website
Volume:
15
Issue:
5
Pages:
1100-1105
Publication date:
2017-01-04
Acceptance date:
2017-01-03
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Source identifiers:
671984
Language:
English
Keywords:
Pubs id:
pubs:671984
UUID:
uuid:f491abfe-10ac-4aae-9493-178277dfb8fe
Local pid:
pubs:671984
Deposit date:
2017-02-01

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