Journal article
Safety, tolerability and pharmacokinetics of single doses of oxytocin administered via an inhaled route in healthy females: randomized, single-blind, phase 1 study
- Abstract:
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Background The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation.
Methods This phase 1, randomized, single-center, single-blind, dose-escalation, fixed-sequence study...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 539.3KB)
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- Publisher copy:
- 10.1016/j.ebiom.2017.07.020
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 22
- Pages:
- 249-255
- Publication date:
- 2017-07-22
- Acceptance date:
- 2017-07-20
- DOI:
- EISSN:
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2352-3964
- Pmid:
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28781129
- Source identifiers:
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1033427
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:1033427
- UUID:
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uuid:f31d3d71-46fd-46c2-ae48-f7fe53fbeacb
- Local pid:
- pubs:1033427
- Deposit date:
- 2019-07-18
Terms of use
- Copyright holder:
- Elsevier BV
- Copyright date:
- 2017
- Notes:
- © 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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