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Journal article

Safety, tolerability and pharmacokinetics of single doses of oxytocin administered via an inhaled route in healthy females: randomized, single-blind, phase 1 study

Abstract:

Background The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation.

Methods This phase 1, randomized, single-center, single-blind, dose-escalation, fixed-sequence study...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2017.07.020

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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
22
Pages:
249-255
Publication date:
2017-07-22
Acceptance date:
2017-07-20
DOI:
EISSN:
2352-3964
Pmid:
28781129
Source identifiers:
1033427
Language:
English
Keywords:
Pubs id:
pubs:1033427
UUID:
uuid:f31d3d71-46fd-46c2-ae48-f7fe53fbeacb
Local pid:
pubs:1033427
Deposit date:
2019-07-18

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