An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng, Y; Felce, SL; Dong, D; Penkava, F; Mentzer, AJ; Yao, X; Liu, G; Yin, Z; Chen, J-L; Lu, Y; Wellington, D; Wing, PAC; Dominey-Foy, DCC; Jin, C; Wang, W; Hamid, MA; Fernandes, RA; Wang, B; Fries, A; Zhuang, X; Ashley, N; Rostron, T; Waugh, C; Sopp, P; Hublitz, P; Beveridge, R; Tan, TK; Dold, C; Kwok, AJ; Rich-Griffin, C; Dejnirattisa, W; Liu, C; Kurupati, P; Nassiri, I; Watson, RA; Tong, O; Taylor, CA; Kumar Sharma, P; Sun, B; Curion, F; Revale, S; Garner, LC; Jansen, K; Ferreira, RC; Attar, M; Fry, JW; Russell, RA; Stauss, HJ; James, W; Townsend, A; Ho, L-P; Klenerman , P; Mongkolsapaya , P; Screaton, GR; Dendrou, C; Sansom , SN; Bashford-Rogers, R; Chain , B; Smith , GL; McKeating, JA; Fairfax, BP; Bowness , P; McMichael, AJ; Ogg, G; Knight, JC; Dong, T

Journal article

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Abstract:: NP_105–113-B*07:02-specific CD8⁺ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP_105–113-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usa...
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Peer review status:: Peer reviewed

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APA Style

Peng, Y., Felce, S. L., Dong, D., Penkava, F., Mentzer, A. J., Yao, X., Liu, G., Yin, Z., Chen, J.-L., Lu, Y., Wellington, D., Wing, P. A. C., Dominey-Foy, D. C. C., Jin, C., Wang, W., Hamid, M. A., Fernandes, R. A., Wang, B., Fries, A., … Dong, T. (2021). An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease. Nature Immunology, 23, 50–61.

MLA Style

Peng, Y., et al. “An Immunodominant NP105–113-B*07:02 Cytotoxic T Cell Response Controls Viral Replication and Is Associated with Less Severe COVID-19 Disease.” Nature Immunology, vol. 23, Springer Nature, 2021, pp. 50–61.

Chicago Style

Peng, Y, SL Felce, D Dong, F Penkava, AJ Mentzer, X Yao, G Liu, et al. 2021. “An Immunodominant NP105–113-B*07:02 Cytotoxic T Cell Response Controls Viral Replication and Is Associated with Less Severe COVID-19 Disease.” Nature Immunology 23: 50–61.
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Publisher copy:: 10.1038/s41590-021-01084-z

Authors

+ Peng, Y More by this author

Role:

Author

ORCID:

0000-0003-2340-0499

+ Felce, SL More by this author

Role:

Author

+ Dong, D More by this author

Role:

Author

+ Penkava, F More by this author

Role:

Author

ORCID:

0000-0001-9163-8576

+ Mentzer, AJ More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Nuffield Department of Population Health

Oxford college:

Keble College

Role:

Author

ORCID:

0000-0002-4502-2209

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Contributors

+ COMBAT Consortium

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Contributor

Funding

+ Medical Research Council More from this funder

Grant:

MR/L018942/1

MR/P021336/1 Crick code 10590

+ Royal Society More from this funder

Grant:

NI140175

+ Wellcome Trust More from this funder

Grant:

097813/Z/11/A

John Fell Fund More from this funder

Bibliographic Details

Publisher:: Springer Nature Publisher's website
Journal:: Nature Immunology Journal website
Volume:: 23
Pages:: 50-61
Publication date:: 2021-12-01
Acceptance date:: 2021-10-26
DOI:: 10.1038/s41590-021-01084-z
EISSN:: 1529-2916
ISSN:: 1529-2908

Item Description

Language:: English
Keywords:: FFR
Pubs id:: 1214619
Local pid:: pubs:1214619
Deposit date:: 2021-12-01

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Copyright holder:: Peng et al.
Rights statement:: Copyright © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Licence:: CC Attribution (CC BY)

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Journal article

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

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