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An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Abstract:

NP105–113-B*07:02-specific CD8+ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105–113-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41590-021-01084-z

Authors


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Role:
Author
ORCID:
0000-0003-2340-0499
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Role:
Author
ORCID:
0000-0001-9163-8576
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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-4502-2209
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Contributors

Role:
Contributor
John Fell Fund More from this funder
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Grant:
MR/L018942/1
MR/P021336/1 Crick code 10590
Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
23
Pages:
50-61
Publication date:
2021-12-01
Acceptance date:
2021-10-26
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Language:
English
Keywords:
Pubs id:
1214619
Local pid:
pubs:1214619
Deposit date:
2021-12-01

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