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A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding

Abstract:

As well as being expressed as a full-length transcript, the group II metabotropic glutamate receptor 3 (GRM3, mGlu3) gene is expressed as an mRNA isoform which lacks exon 4 (GRM3Δ4) and which is predicted to encode a protein with a novel C terminus (called mGlu3 ∆4). This variant may contribute to the mechanism by which GRM3 acts as a schizophrenia risk gene. However, little is known about the properties or function of mGlu3 ∆4. Here, using transiently transfected HEK293T/17 cells, we confirm...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/0269881117715597

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
SAGE Publications Publisher's website
Journal:
Journal of Psychopharmacology Journal website
Volume:
31
Issue:
12
Pages:
1519-1526
Publication date:
2017-06-28
Acceptance date:
2017-05-24
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
Keywords:
Pubs id:
pubs:697645
UUID:
uuid:f0222e5a-f192-47d1-a064-f1d635de5600
Local pid:
pubs:697645
Deposit date:
2017-05-30

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