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The deubiquitylase USP9X controls ribosomal stalling

Abstract:

When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complexes requires activity of Makorin and ZNF598 ubiquitin E3 ligases respectively, through ubiquitylation of the eS10 and uS10 sub-units of the ribosome. It is common for the stability of RING E3 ligase...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2020.04.15.042291

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Institution:
University of Liverpool
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Institution:
University of Liverpool
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
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Author
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Institution:
University of Liverpool
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Institution:
FORMA Therapeutics
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Author
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Publisher:
Cold Spring Harbor Publisher's website
Publication date:
2020-04-17
DOI:
Language:
English
Pubs id:
1102328
Local pid:
pubs:1102328
Deposit date:
2020-04-29

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