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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.

Abstract:

The polymixin colistin is a "last line" antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with a wide geographical distribution and many producer strains resistant to multiple other antibiotics. mcr-1 encodes a membrane-bound enzyme catalysing phosphoethanolamine transfer onto bacterial lipid A. Here we present crystal structures revealing the MCR-1 peripla...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep39392

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Grant:
MR/P007295/1
MR/N002679/1
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
39392
Publication date:
2017-01-06
Acceptance date:
2016-11-22
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
668897
Language:
English
Keywords:
Pubs id:
pubs:668897
UUID:
uuid:ef069830-e2dc-43f3-accc-62decbbe8aa7
Local pid:
pubs:668897
Deposit date:
2017-01-15

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