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Thesis

Fabrication of an aptamer-functionalised silica nanoparticle construct and its separation by magnetic capture-hybridisation

Abstract:

Nanoparticles produced with surfaces functionalised by highly specific molecular tags are able to target aberrant cells and detect or eliminate them without causing damage to surrounding healthy tissues. Single-stranded DNA (ssDNA) and RNA which fold to form secondary or tertiary structures, termed aptamers, represent a new class of such molecular tags. The nanoparticles, in turn, may carry therapeutic payload or luminescent entities which enable elimination or visualisation of targeted ce...

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Institution:
University of Oxford
Oxford college:
Jesus College
Department:
Mathematical,Physical & Life Sciences Division - Engineering Science
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Alicja Bulsiewicz
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:ee1d5b05-f1d0-4336-8831-e54a3daf556a
Local pid:
ora:8483

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