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Variation in structural location and amino acid conservation of functional sites in protein domain families

Abstract:

Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods for the prediction of functional sites are of immense value. Most available methods are based on a set of homologous sequences and structural or evolutionary information, and assume that functional sites are more conserved than the average. In the analysis presented here, we have investigated the conservation of loc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2105-6-210

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Institution:
University of Würzburg
Department:
Department of Bioinformatics
Role:
Author
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Institution:
University of Oxford
Department:
Wellcome Trust Centre for Human Genetics
Role:
Author
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Institution:
University of Würzburg
Department:
Department of Bioinformatics
Role:
Author
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Funding agency for:
Birgit Pils
Publisher:
BioMed Central
Journal:
BMC Bioinformatics Journal website
Volume:
6
Pages:
Article: 210
Publication date:
2005-01-01
DOI:
ISSN:
1471-2105
URN:
uuid:ed0a1189-d699-4839-b227-c49308b43385
Local pid:
ora:2285

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