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Hippocampal acetylcholine depletion has no effect on anxiety, spatial novelty preference, or differential reward for low rates of responding (DRL) performance in rats

Abstract:

We investigated the role of the septo-hippocampal cholinergic projection in anxiety, spatial novelty preference, and differential reward for low rates of responding (DRL) performance. Cholinergic neurons of the rat medial septum (MS) and the vertical limb of the diagonal band of Broca (VDB) were lesioned using the selective immunotoxin, 192 IgG-saporin. Rats were then tested on several behavioral tests previously shown to be sensitive to either (a) hippocampal lesions or (b) nonselective MS/V...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Oxford college:
St Hilda's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Expand authors...
Publisher:
American Psychological Association Publisher's website
Journal:
Behavioral Neuroscience Journal website
Volume:
129
Issue:
4
Pages:
491-501
Place of publication:
United States
Publication date:
2015-08-01
Acceptance date:
2015-04-22
DOI:
EISSN:
1939-0084
ISSN:
0735-7044
Pmid:
26214215
Pubs id:
536087
Local pid:
pubs:536087

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