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Thesis

Investigating the molecular and physiological roles of BUD23-dependent protein translation

Abstract:

The human ribosome is extensively modified, containing at least 288 distinct modification sites. Current literature suggests that most ribosomal modifications serve to stabilise the tertiary structure of the ribosome, however this fails to explain why ribosomal RNA (rRNA) modifications tend to cluster in functionally important regions that are vital for translation. Their spatial organisation and high level of conservation throughout all eukaryotes strongly suggest that rRNA modifications ...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
St Cross College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
ORCID:
0000-0002-2648-6526
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
Institution:
University of Manchester
Role:
Supervisor
More from this funder
Programme:
MRC Doctoral Training Partnership PhD Studentship 2017
Radcliffe Department of Medicine More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-02-21

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