Thesis
Investigating the molecular and physiological roles of BUD23-dependent protein translation
- Abstract:
-
The human ribosome is extensively modified, containing at least 288 distinct modification sites. Current literature suggests that most ribosomal modifications serve to stabilise the tertiary structure of the ribosome, however this fails to explain why ribosomal RNA (rRNA) modifications tend to cluster in functionally important regions that are vital for translation. Their spatial organisation and high level of conservation throughout all eukaryotes strongly suggest that rRNA modifications ...
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Authors
Contributors
+ Hodson, L
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
ORCID:
0000-0002-2648-6526
+ Baxter, M
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
+ Ray, D
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
+ Bechtold, D
Institution:
University of Manchester
Role:
Supervisor
Funding
+ Medical Research Council
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Funder identifier:
http://dx.doi.org/10.13039/501100000265
Radcliffe Department of Medicine
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-02-22
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Terms of use
- Copyright holder:
- Maria Voronkov
- Copyright date:
- 2021
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