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Genome-wide study identifies association between HLA-B∗55:01 and self-reported penicillin allergy

Abstract:

Hypersensitivity reactions to drugs are often unpredictable and can be life threatening, underscoring a need for understanding their underlying mechanisms and risk factors. The extent to which germline genetic variation influences the risk of commonly reported drug allergies such as penicillin allergy remains largely unknown. We extracted data from the electronic health records of more than 600,000 participants from the UK, Estonian, and Vanderbilt University Medical Center's BioVU biobanks t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2020.08.008

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
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NICHD NIH HHS More from this funder
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
107
Issue:
4
Pages:
612-621
Publication date:
2020-08-26
Acceptance date:
2020-08-10
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pmid:
32888428
Language:
English
Keywords:
Pubs id:
1131492
Local pid:
pubs:1131492
Deposit date:
2020-10-27

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