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Journal article

Plasma fucosylated glycans and C-reactive protein as biomarkers of HNF1A-MODY in young adult–onset nonautoimmune diabetes

Abstract:

OBJECTIVE Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the commonest type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diagnosis rates. We previously reported that plasma levels of antennary fucosylated N-glycans and hs-CRP are reduced in individuals with HNF1A-MODY. In this study,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/dc18-0422

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM OCDEM
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM OCDEM
Role:
Author
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Funding agency for:
Juszczak, A
Grant:
George Alberti Fellowship
European Foundation for Study of Diabetes More from this funder
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Funding agency for:
Gloyn, A
Grant:
Senior Fellow: 200837/Z/16/Z
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Care Journal website
Volume:
41
Issue:
12
Publication date:
2018-11-19
Acceptance date:
2018-10-22
DOI:
EISSN:
1935-5548
ISSN:
0149-5992
Source identifiers:
934719
Pubs id:
pubs:934719
UUID:
uuid:e78bc2ac-d12c-4075-9c19-01599845835f
Local pid:
pubs:934719
Deposit date:
2018-10-25

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