Thesis
Structural studies of trans-synaptic complexes
- Abstract:
-
Neuronal synapses are the functional units of the nervous system, allowing the fast transmission of information between neurons. A plethora of proteins populate the cleft between connecting neurons, and many contribute to the formation of protein complexes than span the synaptic cleft. Such trans-synaptic complexes are of tremendous importance for synaptic function, affecting the neuronal wiring specificity, synaptic plasticity or the differentiation of the pre-and post-synaptic compartments....
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Authors
Contributors
+ Aricescu, A
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
+ Siebold, C
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
ORCID:
0000-0002-6635-3621
+ Grunewald, K
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Programme:
NDM Prize Studentship
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2020-09-03
Related Items
Terms of use
- Copyright date:
- 2019
- Rights statement:
- Figures 1-1 and 1-4 were obtained from Sudhof et al, Cell, 2017;171(4):745-69, with permissions received under license number 4901401208467. Figures 1-2 and 1-3 were obtained from Traynelis et al, Pharmacol Rev, 2010;62(3):405- 96, with permissions granted by the letters attached to this thesis. The content of figure 1-2 was originally published in Sobolevsky et al, Nature, 2009;462(7274):745-56 and reproduced here with permissions received under license number 4901930929992. Figure 1-5 was obtained from Elegheert et al, Science, 2016;353(6296):295-9, with permissions received under license number 4901410508937. Figure 1-7 was obtained from Johnson et al, Physiol Rev, 2003;83(1):1-24, with permissions received under license number 4904280652372. Figure 1-8 was obtained from Fuchs et al, Mech Dev, 1998;70(1-2):91-109, with permissions received under license number 4901450106149. Figure 1-9 was obtained from Aricescu et al, EMBO J, 2006;25(4):701-12 and Aricescu et al, Biochem Soc Trans, 2008;36(Pt 2):167-72, with permissions received under license number 4901450627269 (John Wiley and Sons for EMBO J) and license number 1061221- 1 (Biochemical Society).
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