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Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis.

Abstract:
The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis.
Publication status:
Published

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Publisher copy:
10.1002/jbmr.154

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
25
Issue:
8
Pages:
1701-1706
Publication date:
2010-08-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:e76e0df5-e44c-4142-ac4a-54c8a90de49e
Source identifiers:
245103
Local pid:
pubs:245103

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