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Journal article

Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial

Abstract:

BACKGROUND: Inhaled budesonide has shown efficacy for treating COVID-19 in the community but has not yet been tested in effectiveness trials.

METHODS: We performed a multicenter, open-label, multi-arm, adaptive platform randomized controlled trial involving people aged ≥65 years, or ≥50 years with comorbidities, and unwell ≤14 days with suspected COVID-19 in the community (PRINCIPLE). Participants were randomized to usual care, usual care plus inha...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2021.04.10.21254672

Authors


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Institution:
University of Oxford
Division:
MSD
Sub department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0003-0331-7364
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-3003-7918
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-9993-2478
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Primary Care Health Sciences
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-6072-1430
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Primary Care Health Sciences
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0003-0852-627X
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Contributors

Division:
MSD
Oxford college:
Trinity College
Role:
Contributor
Publisher:
Cold Spring Harbor Laboratory Publisher's website
Journal:
medRxiv Journal website
Publication date:
2021-04-12
DOI:
Language:
English
Keywords:
Pubs id:
1171185
Local pid:
pubs:1171185
Deposit date:
2021-05-10

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