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The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

Abstract:

Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. Methods: Individual patient data from AS-AQ clinical trials were pooled using the WorldWide Antimalarial Resistance Network (WWARN) standardised methodology. Risk factors for tr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12916-015-0301-z

Authors


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Bill and Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
13
Issue:
1
Publication date:
2015-01-01
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
Source identifiers:
522723
Keywords:
Pubs id:
pubs:522723
UUID:
uuid:e4d52e32-da19-4b71-80f7-9d0a61936047
Local pid:
pubs:522723
Deposit date:
2015-11-16

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