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Dysregulation of glucagon secretion by hyperglycemia-induced sodium-dependent reduction of ATP production

Abstract:

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tolbutamide and prevented by the sodium-glucose transport (SGLT) inhibitor phlorizin. These data lin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cmet.2018.10.003

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0001-7237-8457
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Metabolism Journal website
Volume:
29
Issue:
2
Pages:
430-442.e4
Publication date:
2018-11-08
Acceptance date:
2018-10-13
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Pmid:
30415925
Source identifiers:
941281
Language:
English
Keywords:
Pubs id:
pubs:941281
UUID:
uuid:e4baf3f3-03a7-4058-a3ae-9c4cc353d00e
Local pid:
pubs:941281
Deposit date:
2019-01-09

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