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Journal article

Chronic Hepatitis C Virus infection subverts vaccine induced T-cell immunity in humans.

Abstract:

Adenoviral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-magnitude, durable CD4+ and CD8+ T-cell responses in healthy volunteers. We assessed the capacity of these vaccines to induce functional HCV-specific immune responses and determine T-cell cross-reactivity to endogenous virus in patients with chronic HCV infection. HCV genotype 1-infected patients were vaccinated using heterologous adenoviral vectors (ChAd3-NSmut and Ad6-NSmut) encoding H...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.28294

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oxford NIHR BioMedical Research Centre
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Funding agency for:
Swadling, L
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Publisher:
Wiley Publisher's website
Journal:
Hepatology Journal website
Pages:
n/a-n/a
Publication date:
2016-01-22
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:e49713b4-3236-4449-8a34-c99890c63317
Source identifiers:
584082
Local pid:
pubs:584082
Language:
English
Keywords:

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