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Substrate conformational dynamics facilitate structure-specific recognition of gapped DNA by DNA polymerase

Abstract:

DNA-binding proteins utilise different recognition mechanisms to locate their DNA targets; some proteins recognise specific DNA sequences, while others interact with specific DNA structures. While sequence-specific DNA binding has been studied extensively, structure-specific recognition mechanisms remain unclear. Here, we study structure-specific DNA recognition by examining the structure and dynamics of DNA polymerase I Klenow Fragment (Pol) substrates both alone and in DNA-Pol complexes. Us...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkz797

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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research
Article number:
gkz797
Publication date:
2019-09-23
Acceptance date:
2019-09-18
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
31544938
Source identifiers:
1055527
Language:
English
Keywords:
Pubs id:
pubs:1055527
UUID:
uuid:e467f0da-df4c-4d04-a06d-d83352b19ad3
Local pid:
pubs:1055527
Deposit date:
2019-10-03

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