Thesis
The function of Ana1 in centrosome assembly, and the regulation of centriole growth in Drosophila
- Abstract:
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Centrioles are microtubule-based structures that play a crucial role in the formation of centrosomes, cilia and flagella. Centriole defects are linked to several human diseases such as microcephaly, primordial dwarfism, cancer and ciliopathies. In Drosophila, Plk4, Sas-6, Ana2, Sas-4 and Asl form a conserved pathway that is essential for centriole assembly. Ana1 was identified as a potential centriole assembly protein in two genome-wide RNAi screens in Drosophila S2 cells, and ana1 mutant ...
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Authors
Contributors
+ Raff, J
Role:
Supervisor
+ Goberdhan, D
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Examiner
+ Wakefield, J
Department:
Living Systems Institute, University of Exeter
Role:
Examiner
Funding
Excellence Master Fellowships, Faculty of Science, University of Geneva, Switzerland
More from this funder
Edward Penley Abraham Scholarship
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:e39b9190-0a2c-48b5-ad2a-c96912e42fce
- Deposit date:
- 2019-03-13
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Terms of use
- Copyright holder:
- Saroj Saurya and Jordan Raff
- Copyright date:
- 2018
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