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Thesis

The function of Ana1 in centrosome assembly, and the regulation of centriole growth in Drosophila

Abstract:

Centrioles are microtubule-based structures that play a crucial role in the formation of centrosomes, cilia and flagella. Centriole defects are linked to several human diseases such as microcephaly, primordial dwarfism, cancer and ciliopathies. In Drosophila, Plk4, Sas-6, Ana2, Sas-4 and Asl form a conserved pathway that is essential for centriole assembly. Ana1 was identified as a potential centriole assembly protein in two genome-wide RNAi screens in Drosophila S2 cells, and ana1 mutant ...

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Copyright Holder, Author

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Role:
Copyright Holder, Supervisor
Department:
Department of Physiology, Anatomy and Genetics, University of Oxford
Role:
Examiner
Department:
Living Systems Institute, University of Exeter
Role:
Examiner
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Grant:
Senior Investigator Award 104575
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Grant:
Strategic Award 107457
Funding agency for:
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Grant:
Strategic Award 091911
Funding agency for:
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Grant:
PhD studentship
Funding agency for:
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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