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SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

Abstract:

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor hypoxia and a rational target to overcome it have been sought to realize personalized radiotherapy. Here, we show that serine protease inhibitor Kazal type I (SPINK1) meets these 2 criteria. SPINK1 expression was induced upon hypoxia (O2 < 0.1%) at the transcription initiation level in a HIF-dependent manner, causing an increase in secreted SPINK1 levels. SPINK1 proteins were detected both within and ar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.148135

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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
6
Issue:
21
Article number:
e148135
Publication date:
2021-11-08
Acceptance date:
2021-09-24
DOI:
EISSN:
2379-3708
Language:
English
Keywords:
Pubs id:
1207616
Local pid:
pubs:1207616
Deposit date:
2021-11-09

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