Journal article
Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads
- Abstract:
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From their early roots in natural products, peptides now represent an expanding class of novel drugs. Their modular structures make them ideal candidates for pooled library screening approaches. Key technologies for library generation and screening, such as SICLOPPS, phage display and mRNA display, give unparalleled access to tight binding peptides. Through combination with genetic code reprogramming and chemical modifications, access to more natural product-like libraries, spanning non-canon...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 2.4MB)
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- Publisher copy:
- 10.1016/j.cbpa.2017.02.020
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Authors
Funding
657292/European Union’s Horizon 2020 research and innovation programme
More from this funder
+ Japan Science and Technology Agency
More from this funder
Grant:
CoreResearchforEvolutionalScience
Technology(CREST)ofMolecularTechnologies
+ Japan Society for the Promotion of Science
More from this funder
Grant:
Grant-in-AidScientificResearch(S)(26220204)toH.S.
Grants-in-AidforJSPSFellowstoR.O.(P15333
+ European Union
More from this funder
Grant:
Horizon 2020 Marie Skłodowska-Curie grant agreement no. 657292
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Current Opinion in Chemical Biology Journal website
- Volume:
- 38
- Issue:
- June 2017
- Pages:
- 52-61
- Publication date:
- 2017-03-17
- Acceptance date:
- 2017-01-26
- DOI:
- EISSN:
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1879-0402
- ISSN:
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1367-5931
- Source identifiers:
-
689122
Item Description
- Pubs id:
-
pubs:689122
- UUID:
-
uuid:e080c6e5-467d-40c2-a7e0-4bf9a75a9f05
- Local pid:
- pubs:689122
- Deposit date:
- 2017-04-12
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: 10.1016/j.cbpa.2017.02.020
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