Journal article icon

Journal article

Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads

Abstract:

From their early roots in natural products, peptides now represent an expanding class of novel drugs. Their modular structures make them ideal candidates for pooled library screening approaches. Key technologies for library generation and screening, such as SICLOPPS, phage display and mRNA display, give unparalleled access to tight binding peptides. Through combination with genetic code reprogramming and chemical modifications, access to more natural product-like libraries, spanning non-canon...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cbpa.2017.02.020

Authors


More by this author
Institution:
University of Oxford
Oxford college:
St Edmund Hall
Role:
Author
657292/European Union’s Horizon 2020 research and innovation programme More from this funder
More from this funder
Grant:
CoreResearchforEvolutionalScience
Technology(CREST)ofMolecularTechnologies
More from this funder
Grant:
Grant-in-AidScientificResearch(S)(26220204)toH.S.
Grants-in-AidforJSPSFellowstoR.O.(P15333
More from this funder
Grant:
Horizon 2020 Marie Skłodowska-Curie grant agreement no. 657292
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Chemical Biology Journal website
Volume:
38
Issue:
June 2017
Pages:
52-61
Publication date:
2017-03-17
Acceptance date:
2017-01-26
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Source identifiers:
689122
Pubs id:
pubs:689122
UUID:
uuid:e080c6e5-467d-40c2-a7e0-4bf9a75a9f05
Local pid:
pubs:689122
Deposit date:
2017-04-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP