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Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells

Abstract:

During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN(+) cells, become significantly depleted in the blood and lymphoid tissues of AIDS patients, which may contribute to the failure in initiating effective host immune responses. The mechanism for DC depletion, however, is unclear. It is known that vast quantit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1003100

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Editor
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
9
Issue:
1
Pages:
e1003100
Publication date:
2013-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
376254

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