Thesis
Investigating the biology of nuclear IGF-1R in prostate cancer
- Abstract:
-
Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase comprised of two extracellular α- and two transmembrane β-subunits in a heterotetrameric structure. IGF-axis signalling is implicated in cancer progression, metastasis and resistance to treatment including radiotherapy. Recent work by our lab and others has shown the presence and activity of IGF-1R in the nucleus of a range of cancer cell types, interacting with nuclear proteins and undergoing recrui...
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Authors
Contributors
+ Macaulay, V
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Research group:
Macaulay Lab
Role:
Supervisor
ORCID:
0000-0001-8659-0192
+ Mills, I
Role:
Supervisor
+ Humphrey, T
Division:
MSD
Department:
Oncology
Role:
Examiner
+ Lin, Y
Institution:
Karolinska Institute
Role:
Examiner
Funding
+ Cancer Research UK
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000289
Funding agency for:
Macaulay, V
Mills, JV
Grant:
CRUKDF - 0221 – VMIMJM
+ Medical Research Council
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Funding agency for:
Mills, JV
Grant:
1718_MSD_1113081
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-06-06
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Terms of use
- Copyright holder:
- Mills, JV
- Copyright date:
- 2021
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