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Fine-mapping inflammatory bowel disease loci to single-variant resolution

Abstract:

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few have been conclusively resolved to specific functional variants. Here we report fine-mapping of 94 inflammatory bowel disease loci using high-density genotyping in 67,852 individuals. We pinpoint 18 associations to a single causal variant with greater than 95% certainty,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature22969

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Kennedy Institute of Rheumatology
Oxford college:
Christ Church
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
547
Pages:
173–178
Publication date:
2017-07-13
Acceptance date:
2017-05-07
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
28658209
Source identifiers:
702240

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