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Journal article

Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.

Abstract:

1. Tetrahydrobiopterin (BH(4)) is an essential cofactor that maintains the normal function of endothelial nitric oxide (NO) synthase. Restenosis is a key complication after transluminal angioplasty. Guanosine 5'-triphosphate-cyclohydrolase I (GTPCH) is the first rate-limiting enzyme for de novo BH(4) synthesis. However, the role of GTPCH in restenosis is not fully understood. The present study tested the hypothesis that endothelial-targeted GTPCH overexpression retards neointimal formation, a...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
Clinical and experimental pharmacology and physiology
Volume:
34
Issue:
12
Pages:
1260-1266
Publication date:
2007-12-01
DOI:
EISSN:
1440-1681
ISSN:
0305-1870
Source identifiers:
105330
Language:
English
Keywords:
Pubs id:
pubs:105330
UUID:
uuid:def54447-ece9-488b-97dc-b558da00dedd
Local pid:
pubs:105330
Deposit date:
2012-12-19

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