Journal article
Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells
- Abstract:
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The transcriptional repressor Blimp-1 originally cloned as a silencer of type I interferon (IFN)-β gene expression controls cell fate decisions in multiple tissue contexts. Conditional inactivation in the mammary gland was recently shown to disrupt epithelial cell architecture. Here we report that Blimp-1 regulates expression of viral defense, IFN signaling and MHC class I pathways, and directly targets the transcriptional activator Stat1. Blimp-1 functional loss in 3D cultures of mammary epi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.3MB)
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- Publisher copy:
- 10.1038/s41598-017-18652-9
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Article number:
- 237
- Publication date:
- 2018-01-10
- Acceptance date:
- 2017-12-15
- DOI:
- EISSN:
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2045-2322
- ISSN:
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2045-2322
- Pmid:
-
29321612
- Source identifiers:
-
820917
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:820917
- UUID:
-
uuid:de5c8327-64a3-4214-a288-e20081a8f30f
- Local pid:
- pubs:820917
- Deposit date:
- 2018-01-29
Terms of use
- Copyright holder:
- Elias et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This work is licensed under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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