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Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Abstract:

Parasites infect hosts in widely varying environments, encountering diverse challenges for adaptation. To identify malaria parasite genes under locally divergent selection across a large endemic region with a wide spectrum of transmission intensity, genome sequences were obtained from 284 clinical Plasmodium falciparum infections from four newly sampled locations in Senegal, The Gambia, Mali and Guinea. Combining these with previous data from seven other sites in West Africa enabled a multi-p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-9359-4888
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Role:
Author
ORCID:
0000-0003-4478-3601
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Role:
Author
ORCID:
0000-0002-4268-8857
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Role:
Author
ORCID:
0000-0002-8793-3641
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Issue:
2018
Article number:
15763
Publication date:
2018-10-25
Acceptance date:
2018-10-11
DOI:
ISSN:
2045-2322
Pmid:
30361631
Pubs id:
pubs:1037107
UUID:
uuid:de229ed2-d0e2-4a4c-954c-935b7f362a84
Source identifiers:
1037107
Local pid:
pubs:1037107
Language:
English
Keywords:

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