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Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis

Abstract:

Pleiotrophin (PTN) is a secreted cytokine that is expressed in various cancer cell lines and human tumor such as colon cancer, lung cancer, gastric cancer and melanoma. It plays significant roles in angiogenesis, metastasis, differentiation and cell growth. The expression of PTN in the adult is limited to the hippocampus in an activity-dependent manner, making it a very attractive target for cancer therapy. RNA interference (RNAi) offers great potential as a new powerful therapeutic strategy ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0177964

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
5
Pages:
Article: e0177964
Publication date:
2017-05-31
Acceptance date:
2017-05-05
DOI:
ISSN:
1932-6203
Pubs id:
pubs:697995
URN:
uri:ddcbbdff-e511-4bd5-b662-75c4f5dbcee6
UUID:
uuid:ddcbbdff-e511-4bd5-b662-75c4f5dbcee6
Local pid:
pubs:697995
Paper number:
5
Language:
English

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