Journal article
Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis
- Abstract:
-
Pleiotrophin (PTN) is a secreted cytokine that is expressed in various cancer cell lines and human tumor such as colon cancer, lung cancer, gastric cancer and melanoma. It plays significant roles in angiogenesis, metastasis, differentiation and cell growth. The expression of PTN in the adult is limited to the hippocampus in an activity-dependent manner, making it a very attractive target for cancer therapy. RNA interference (RNAi) offers great potential as a new powerful therapeutic strategy ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 3.8MB)
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- Publisher copy:
- 10.1371/journal.pone.0177964
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Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 12
- Issue:
- 5
- Pages:
- Article: e0177964
- Publication date:
- 2017-05-31
- Acceptance date:
- 2017-05-05
- DOI:
- ISSN:
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1932-6203
- Pubs id:
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pubs:697995
- URN:
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uri:ddcbbdff-e511-4bd5-b662-75c4f5dbcee6
- UUID:
-
uuid:ddcbbdff-e511-4bd5-b662-75c4f5dbcee6
- Local pid:
- pubs:697995
- Paper number:
- 5
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- Zha et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Zha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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