Journal article icon

Journal article

Combining simple blood tests to identify primary care patients with unexpected weight loss for cancer investigation: clinical risk score development, internal validation, and net benefit analysis

Abstract:

Background
Unexpected weight loss (UWL) is a presenting feature of cancer in primary care. Existing research proposes simple combinations of clinical features (risk factors, symptoms, signs, and blood test data) that, when present, warrant cancer investigation. More complex combinations may modify cancer risk to sufficiently rule-out the need for investigation. We aimed to identify which clinical features can be used together to stratify patients with UWL based on the... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.1003728

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0003-0661-7362
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0002-1802-4217
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-9821-7608
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0003-2418-2091
More by this author
Role:
Author
ORCID:
0000-0003-1611-1373
Expand authors...
Department of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
18
Issue:
8
Article number:
e1003728
Place of publication:
United States
Publication date:
2021-08-31
Acceptance date:
2021-07-12
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pmid:
34464384
Language:
English
Keywords:
Pubs id:
1193745
Local pid:
pubs:1193745
Deposit date:
2021-12-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP