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An in vitro model for the development of mature bone containing an osteocyte network

Abstract:

Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli. This process can also result in maladaptive ectopic bone in response to injury, yet pathological differences at the molecular and structural levels are poorly understood. A number of in vivo models exist but can often be too complex to allow isolation of factors which may stimulate disease progression. A self-structuring model of bone formation is presented using a fibrin gel cast between...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/adbi.201700156

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Advanced Biosystems Journal website
Volume:
2
Issue:
2
Article number:
1700156
Publication date:
2017-12-22
Acceptance date:
2017-10-16
DOI:
EISSN:
2366-7478
Source identifiers:
822213
Keywords:
Pubs id:
pubs:822213
UUID:
uuid:dca1832d-c485-434c-8f83-b660a2aa0955
Local pid:
pubs:822213
Deposit date:
2018-02-01

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