Journal article
An in vitro model for the development of mature bone containing an osteocyte network
- Abstract:
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Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli. This process can also result in maladaptive ectopic bone in response to injury, yet pathological differences at the molecular and structural levels are poorly understood. A number of in vivo models exist but can often be too complex to allow isolation of factors which may stimulate disease progression. A self-structuring model of bone formation is presented using a fibrin gel cast between...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.2MB)
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- Publisher copy:
- 10.1002/adbi.201700156
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Authors
Funding
+ National Centre for the Replacement Refinement and Reduction of animals in research
More from this funder
Grant:
NC3Rs) grant (NC/L001403/1
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Advanced Biosystems Journal website
- Volume:
- 2
- Issue:
- 2
- Article number:
- 1700156
- Publication date:
- 2017-12-22
- Acceptance date:
- 2017-10-16
- DOI:
- EISSN:
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2366-7478
- Source identifiers:
-
822213
Item Description
- Keywords:
- Pubs id:
-
pubs:822213
- UUID:
-
uuid:dca1832d-c485-434c-8f83-b660a2aa0955
- Local pid:
- pubs:822213
- Deposit date:
- 2018-02-01
Terms of use
- Copyright holder:
- Iordachescu et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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