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High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets

Abstract:

Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model for the environment experienced by human islets in a confined space present during culture, shipment, and in an implanted macrodevice. Quadruplicate aliquots of isolated human islets (n = 12) were cultured for 24 h at 37°C under normoxic conditio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3727/096368915x689929

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0001-5117-4447
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
St Edmund Hall
Role:
Author
National Institute for Health Research More from this funder
Juvenile Diabetes Research Foundation More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Cell Transplantation Journal website
Volume:
25
Issue:
8
Pages:
1539-1546
Publication date:
2016-08-01
DOI:
EISSN:
1555-3892
ISSN:
0963-6897
Pmid:
26628048
Source identifiers:
586326

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