Thesis
Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling
- Abstract:
-
Recent studies have identified Two-Pore Channels (TPCs) as the channels activated by NAADP. To date, most studies that characterized these channels have employed heterologous expression or overexpression systems. The research reported here has focused principally on endogenous TPC activity by using single and dual gene knockout (KO) in a mouse system and has yielded insights into TPC expression levels, subcellular localisation, NAADP binding, and channel function.
Mouse models that ...
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Funding
+ Christopher Welch Scholarship and Clarendon Fund
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Funding agency for:
Chuang, KT
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:dbf87d55-4266-4fa9-9eef-5214e7f4cd01
- Local pid:
- ora:6761
- Deposit date:
- 2013-03-18
Terms of use
- Copyright holder:
- Chuang, KT
- Copyright date:
- 2011
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