Thesis
Examining the contribution of dentate gyrus granule cells and ambiguity toward the stress response and behaviour of the rodent
- Abstract:
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The hippocampus and adult-born neurons have been implicated in regulating the stress response and disambiguating conflicting goal-related information. How these functions interact to promote adaptive behaviour has not been investigated. In this thesis, hippocampal lesions or pharmaco-genetic ablation of adult neurogenesis in mice ('TK mice') was used to dissect this relationship. Hippocampal lesions or selectively ablating adult neurogenesis decreased defensive behaviours toward a partiall...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
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- Subjects:
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- Copyright date:
- 2016
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