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Thesis

Examining the contribution of dentate gyrus granule cells and ambiguity toward the stress response and behaviour of the rodent

Abstract:

The hippocampus and adult-born neurons have been implicated in regulating the stress response and disambiguating conflicting goal-related information. How these functions interact to promote adaptive behaviour has not been investigated. In this thesis, hippocampal lesions or pharmaco-genetic ablation of adult neurogenesis in mice ('TK mice') was used to dissect this relationship. Hippocampal lesions or selectively ablating adult neurogenesis decreased defensive behaviours toward a partiall...

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Department:
Nuffield Department of Medicine
Role:
Author

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Department:
Experimental Psychology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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