Journal article
Potent cross-reactive antibodies following Omicron breakthrough in vaccinees
- Abstract:
-
Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD has slightly higher ACE2 affinity than BA.1 and slightly reduced neutralization by vaccine serum, possibly associated with its increased transmissibility. Neutralization differences between sub-lineages for mAbs (including therapeutics) mostly arise from variation in residues bordering the ACE2 binding site; however, more distant mutation...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Funding
National Institute for Health Research
More from this funder
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 185
- Issue:
- 12
- Pages:
- 2116-2131.e18
- Publication date:
- 2022-05-20
- Acceptance date:
- 2022-05-14
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pmid:
-
35662412
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1262790
- Local pid:
- pubs:1262790
- Deposit date:
- 2022-07-14
Terms of use
- Copyright holder:
- Nutalai et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record