Journal article
Dicer dependent tRNA derived small RNAs promote nascent RNA silencing
- Abstract:
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In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target messenger RNA (mRNA) or inhibition of translation in the cytoplasm, and transcriptional gene silencing (TGS), which is mediated by the establishment of repressive epigenetic marks at target loci. Transfer RNAs (tRNAs), which are essential for translat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 3.3MB, Terms of use)
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- Publisher copy:
- 10.1093/nar/gkac022
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Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Nucleic Acids Research More from this journal
- Volume:
- 50
- Issue:
- 3
- Pages:
- 1734-1752
- Publication date:
- 2022-01-20
- Acceptance date:
- 2022-01-10
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
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1233247
- Local pid:
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pubs:1233247
- Deposit date:
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2022-01-24
Terms of use
- Copyright holder:
- Di Fazio et al
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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