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Dicer dependent tRNA derived small RNAs promote nascent RNA silencing

Abstract:

In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target messenger RNA (mRNA) or inhibition of translation in the cytoplasm, and transcriptional gene silencing (TGS), which is mediated by the establishment of repressive epigenetic marks at target loci. Transfer RNAs (tRNAs), which are essential for translat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkac022

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-4512-2779
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
50
Issue:
3
Pages:
1734-1752
Publication date:
2022-01-20
Acceptance date:
2022-01-10
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
1233247
Local pid:
pubs:1233247
Deposit date:
2022-01-24

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