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Thesis

The role of G protein alpha 11 in calcium and glucose homeostasis

Abstract:

Guanine nucleotide-binding (G) proteins act as molecular switches to transduce stimuli received by G protein-coupled receptors (GPCRs) into intracellular responses. For example, Gα11 mediates signalling by the calcium-sensing receptor (CaSR), a class C GPCR, to regulate calcium homeostasis. Germline CaSR and Gα11 inactivating and activating mutations cause calcitropic disorders such as familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant hypocalcaemia (ADH) types-1 and -2, re...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Academic Endocrine Unit
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0003-3459-2764

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Academic Endocrine Unit
Role:
Supervisor
ORCID:
0000-0002-1438-3220
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Academic Endocrine Unit
Oxford college:
St Hilda's College
Role:
Supervisor
ORCID:
0000-0002-0764-8681
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Examiner
ORCID:
0000-0002-4136-1828
Institution:
University of Cambridge
Role:
Examiner
ORCID:
0000-0002-2654-8854
More from this funder
Programme:
ETN CaSR Biomedicine
Funding agency for:
Thakker, RV
More from this funder
Funding agency for:
Thakker, RV
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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