Journal article
Structure of the ultra-high-affinity colicin E2 DNase-Im2 complex
- Abstract:
-
How proteins achieve high-affinity binding to a specific protein partner while simultaneously excluding all others is a major biological problem that has important implications for protein design. We report the crystal structure of the ultra-high-affinity protein-protein complex between the endonuclease domain of colicin E2 and its cognate immunity (Im) protein, Im2 (K d∼ 10 -15 M), which, by comparison to previous structural and biophysical data, provides unprecedented insight into how high ...
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- Publisher copy:
- 10.1016/j.jmb.2012.01.019
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Authors
Bibliographic Details
- Journal:
- Journal of Molecular Biology
- Volume:
- 417
- Issue:
- 1-2
- Pages:
- 79-94
- Publication date:
- 2012-03-16
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- Source identifiers:
-
320755
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:320755
- UUID:
-
uuid:d62aa90d-34bc-4474-9a8c-d2837956a703
- Local pid:
- pubs:320755
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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