Journal article
Fumarate hydratase deletion in pancreatic beta cells leads to progressive diabetes
- Abstract:
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We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycemia in Fh1βKO mice led to dysregulated metabolism in β cells, a decrease in glucose-induced ATP pr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.1MB)
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- Publisher copy:
- 10.1016/j.celrep.2017.08.093
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Authors
Funding
+ Spanish Ministry of Science and Technology
More from this funder
Funding agency for:
Martín-Del-Río, R
Grant:
SAF2009/1267
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 20
- Issue:
- 13
- Pages:
- 3135-3148
- Publication date:
- 2017-09-26
- Acceptance date:
- 2017-08-29
- DOI:
- EISSN:
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2211-1247
- ISSN:
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2211-1247
- Pmid:
-
28954230
- Source identifiers:
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731155
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:731155
- UUID:
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uuid:d592f689-b891-493b-ac78-7070faa19ae8
- Local pid:
- pubs:731155
- Deposit date:
- 2017-10-14
Terms of use
- Copyright holder:
- © 2017 Adam, et al
- Copyright date:
- 2017
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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