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Journal article

Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies

Abstract:

Objectives
Autoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan’s syndrome and neuromyotonia. However, in routine testing, VGKC-complex-antibodies without LGI1- or CASPR2-reactivities (“double-negative”) are commoner than LGI1- or CASPR2-specificities. Ther...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2016-314758

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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More from this funder
Funding agency for:
Irani, S
Grant:
Vera Down Grant
More from this funder
Funding agency for:
Irani, S
Grant:
Vera Down Grant
More from this funder
Funding agency for:
Irani, S
Grant:
Vera Down Grant
More from this funder
Funding agency for:
Irani, S
Grant:
Vera Down Grant
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Publication date:
2017-01-23
Acceptance date:
2016-12-01
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Language:
English
Keywords:
Pubs id:
pubs:664848
UUID:
uuid:d54a3596-b855-46fb-a0db-87a3caed4c31
Local pid:
pubs:664848
Deposit date:
2016-12-09

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