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Nanog fluctuations in embryonic stem cells highlight the problem of measurement in cell biology

Abstract:

A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abundances cannot be measured directly in live cells, fluctuations are typically assessed using geneticall...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2017.05.005

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Funding agency for:
Harrington, H
Publisher:
Biophysical Journal Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
112
Issue:
12
Pages:
2641-2652
Publication date:
2017-06-20
Acceptance date:
2017-05-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pmid:
28636920
Source identifiers:
702411

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