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Thesis

Theoretical advances in the modelling and interrogation of biochemical reaction systems: alternative formulations of the chemical Langevin equation and optimal experiment design for model discrimination

Abstract:

This thesis is concerned with methodologies for the accurate quantitative modelling of molecular biological systems. The first part is devoted to the chemical Langevin equation (CLE), a stochastic differential equation driven by a multidimensional Wiener process. The CLE is an approximation to the standard discrete Markov jump process model of chemical reaction kinetics. It is valid in the regime where molecular populations are abundant enough to assume their concentrations change continuo...

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Institution:
University of Oxford
Oxford college:
Keble College
Department:
Mathematical,Physical & Life Sciences Division - Other - Life Sciences Interface Doctoral Training Centre
Role:
Author

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Role:
Supervisor
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d368c04c-b611-41b2-8866-cde16b283b0d
Local pid:
ora:5318

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