Thesis
Theoretical advances in the modelling and interrogation of biochemical reaction systems: alternative formulations of the chemical Langevin equation and optimal experiment design for model discrimination
- Abstract:
-
This thesis is concerned with methodologies for the accurate quantitative modelling of molecular biological systems. The first part is devoted to the chemical Langevin equation (CLE), a stochastic differential equation driven by a multidimensional Wiener process. The CLE is an approximation to the standard discrete Markov jump process model of chemical reaction kinetics. It is valid in the regime where molecular populations are abundant enough to assume their concentrations change continuo...
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Authors
Contributors
+ Etheridge, A
Division:
MPLS
Department:
Statistics
Role:
Supervisor
+ Papachristodoulou, A
Division:
MPLS
Department:
Statistics
Role:
Supervisor
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Mélykúti, B
Grant:
EP/E501605/1
Bibliographic Details
- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:d368c04c-b611-41b2-8866-cde16b283b0d
- Local pid:
- ora:5318
- Deposit date:
- 2011-05-17
Terms of use
- Copyright holder:
- Mélykúti, B
- Copyright date:
- 2010
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